| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-Ras-Related Protein Rab-4a is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S5119RM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RAB4A |
| Gene ID: |
5867 |
| Uniprot ID: |
RAB4A_HUMAN |
| Immunogen: |
Recombinant protein of human RAB4A. |
| Post Translational Modifications | Phosphorylated by CDK1 kinase during mitosis. Serotonylation of Gln-72 by TGM2 during activation and aggregation of platelets leads to constitutive activation of GTPase activity. |
| Function | Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Involved in protein transport. Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling. Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets. |
| Protein Name | Ras-Related Protein Rab-4a |
| Database Links | Reactome: R-HSA-1445148Reactome: R-HSA-1660499Reactome: R-HSA-8854214Reactome: R-HSA-8873719Reactome: R-HSA-8875656 |
| Cellular Localisation | MembranePeripheral Membrane ProteinCytoplasmEarly Endosome MembraneRecycling Endosome MembraneGenerally Associated With MembranesCytoplasmic When Phosphorylated By Cdk1 |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-4a antibodyAnti-RAB4A antibodyAnti-RAB4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
