| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RAB3IP |
| Gene ID: | 117177 |
| Uniprot ID: | RAB3I_HUMAN |
| Immunogen Region: | 1-150 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human RAB3IP (NP_071901.2). |
| Immunogen Sequence: | MANDPLEGFHEVNLASPTSP DLLGVYESGTQEQTTSPSVI YRPHPSALSSVPIQANALDV SELPTQPVYSSPRRLNCAEI SSISFHVTDPAPCSTSGVTA GLTKLTTRKDNYNAEREFLQ GATITEACDGSDDIFGLSTD SLSRLRSPSV |
| Tissue Specificity | Expressed in brain, kidney, heart, pancreas and placenta. Not detected in skeletal muscle or liver. |
| Post Translational Modifications | Phosphorylated by AKT1.the phosphorylation alters its GEF activity. |
| Function | Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Part of the ciliary targeting complex containing Rab11, ASAP1, RAB3IP and RAB11FIP3 and ARF4 that promotes RAB3IP preciliary vesicle trafficking to mother centriole and ciliogenesis initiation. |
| Protein Name | Rab-3a-Interacting Protein Rab3a-Interacting Protein Rabin-3 Rabin8 Ssx2-Interacting Protein |
| Database Links | Reactome: R-HSA-5620912 Reactome: R-HSA-5620916 Reactome: R-HSA-5620922 Reactome: R-HSA-8876198 |
| Cellular Localisation | Cytoplasm Nucleus Cytoskeleton Cell Projection Lamellipodium Vesicle Microtubule Organizing Center Centrosome Predominantly Cytoplasmic But A Small Proportion Colocalizes With Ssx2 In The Nucleus Activation Of Protein Kinase C Results In Redistribution To The Periphery Of Lamellipodia |
| Alternative Antibody Names | Anti-Rab-3a-Interacting Protein antibody Anti-Rab3a-Interacting Protein antibody Anti-Rabin-3 antibody Anti-Rabin8 antibody Anti-Ssx2-Interacting Protein antibody Anti-RAB3IP antibody Anti-RABIN8 antibody |
Information sourced from Uniprot.org