| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RAB3GAP1 |
| Gene ID: |
22930 |
| Uniprot ID: |
RB3GP_HUMAN |
| Immunogen Region: |
500-780 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 500-780 of human RAB3GAP1 (NP_001165906.1). |
| Immunogen Sequence: |
GLASGPPDLRCCLLHQKLQM LNCCIERKKARDEGKKTSAS DVTNIYPGDAGKAGDQLVPD NLKETDKEKGEVGKSWDSWS DSEEEFFECLSDTEELKGNG QESGKKGGPKEMANLRPEGR LYQHGKLTLLHNGEPLYIPV TQEPAPMTEDLLEEQSEVLA KLGTSAEGAHLRARMQSACL LSDMESFKAANPGCSLEDFV RWYSPRDYIEEEVIDEKGNV VLKGELSARMKIPSNMWVE |
| Tissue Specificity | Ubiquitous. |
| Function | Catalytic subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18. As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. The Rab3GAP complex, acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP. Required for recruiting and activating RAB18 at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters. |
| Protein Name | Rab3 Gtpase-Activating Protein Catalytic SubunitRab3 Gtpase-Activating Protein 130 Kda SubunitRab3-Gap P130Rab3-Gap |
| Database Links | Reactome: R-HSA-6811436Reactome: R-HSA-8876198 |
| Cellular Localisation | CytoplasmEndoplasmic ReticulumIn NeuronsIt Is Enriched In The Synaptic Soluble Fraction |
| Alternative Antibody Names | Anti-Rab3 Gtpase-Activating Protein Catalytic Subunit antibodyAnti-Rab3 Gtpase-Activating Protein 130 Kda Subunit antibodyAnti-Rab3-Gap P130 antibodyAnti-Rab3-Gap antibodyAnti-RAB3GAP1 antibodyAnti-KIAA0066 antibodyAnti-RAB3GAP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
