| Host: |
Rabbit |
| Applications: |
WB/ELISA/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Ras-related protein Rab-35 (99-148 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RAB35 |
| Gene ID: |
11021 |
| Uniprot ID: |
RAB35_HUMAN |
| Immunogen Region: |
99-148 aa |
| Specificity: |
Rab 35 Polyclonal Antibody detects endogenous levels of Rab 35 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human RAB35 at the amino acid range 99-148 |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. May indirectly regulate neurite outgrowth. Together with TBC1D13 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes. |
| Protein Name | Ras-Related Protein Rab-35Gtp-Binding Protein RayRas-Related Protein Rab-1c |
| Database Links | Reactome: R-HSA-8854214Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideMembraneClathrin-Coated PitCytoplasmic VesicleClathrin-Coated VesicleEndosomeMelanosomePresent On Sorting Endosomes And Recycling Endosome TubulesTends To Be Enriched In Pip2-Positive Cell Membrane DomainsDuring MitosisAssociated With The Plasma Membrane And Present At The Ingressing Furrow During Early Cytokinesis As Well As At The Intercellular Bridge Later During CytokinesisIdentified In Stage I To Stage Iv Melanosomes |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-35 antibodyAnti-Gtp-Binding Protein Ray antibodyAnti-Ras-Related Protein Rab-1c antibodyAnti-RAB35 antibodyAnti-RAB1C antibodyAnti-RAY antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
