Anti-RAB2B antibody (C-Term) (STJ140109)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant peptide derived from within residues 300 aa to the C-terminus of human ERp57 produced in E. coli.
General Information
| Short Description | Goat polyclonal RAB2b, member RAS oncogene family (C-Term) antibody for use in WB in human, mouse, rat, bovine, canine, chicken, avian, donkey, feline, goat, guinea pig, hamster, horse, porcine, rabbit, sheep and simian samples. Datasheet included wi |
| Applications | WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Bovine/Canine/Chicken/Avian/Donkey/Feline/Goat/Guinea Pig/Hamster/Horse/Porcine/Rabbit/Sheep/Simian |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 3 mg/mL |
| Purification | This antibody is epitope-affinity purified from goat antiserum. |
| Dilution Range | WB 1:250-1:2000 |
| Formulation | PBS, 20% Glycerol and 0.05% Sodium Azide. |
Target Information
| Gene Symbol | RAB2B |
| Gene ID | 84932 |
| Uniprot ID | RAB2B_HUMAN |
| Accession Number | ENSG00000129472 |
| Immunogen | Recombinant peptide derived from within residues 300 aa to the C-terminus of human ERp57 produced in E. coli. |
| Immunogen Region | C-Term |
| Immunogen Sequence | MGNKSDLESRRDVKREEGEA GNKSDLESRRDVKREEGEAF NKSDLESRRDVKREEGEAFA KSDLESRRDVKREEGEAFAR SDLESRRDVKREEGEAFARE |
| Specificity | Detects levels of Rab2b protein in transfected cells with GFP-Rab2b by Western blot. This antibody is specific for Rab2b and it barely detects Rab2a. |
Additional Info
| Tissue Specificity | Expressed in kidney, prostate, lung, liver, thymus, colon, pancreas, and skeletal muscle, and low levels in placenta. Not detected in heart, brain, spleen, testis, ovary, small intestine and leukocyte. |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Regulates the compacted morphology of the Golgi (Probable). Promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis. Together with RAB2A redundantly required for efficient autophagic flux. |
| Protein Name | Ras-Related Protein Rab-2b |
| Database Links | Reactome: R-HSA-8873719 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideEndoplasmic Reticulum MembraneGolgi Apparatus MembraneCytoplasmic VesicleSecretory VesicleAcrosomeAutophagosome MembraneLocalized In The Golgi Apparatus In The Round Spermatids And In The Acrosome In The Elongating Spermatid |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-2b antibodyAnti-RAB2B antibody |
Information sourced from Uniprot.org