Anti-RAB18 antibody (103-152 aa) (STJ95285)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human RAB18 at the amino acid range 103-152
General Information
| Short Description | Rabbit polyclonal anti-Ras-related protein Rab-18 (103-152 aa) for use in WB, ELISA and IHC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RAB18 |
| Gene ID | 22931 |
| Uniprot ID | RAB18_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human RAB18 at the amino acid range 103-152 |
| Immunogen Region | 103-152 aa |
| Specificity | Rab 18 Polyclonal Antibody detects endogenous levels of Rab 18 protein. |
Additional Info
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB18 is required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts. Also required for maintaining endoplasmic reticulum structure. Plays a role in apical endocytosis/recycling. Plays a key role in eye and brain development and neurodegeneration. |
| Protein Name | Ras-Related Protein Rab-18 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-6811436Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Endoplasmic Reticulum MembraneGolgi ApparatusCis-Golgi Network MembraneLipid DropletApical Cell MembraneLocalized To The Er Membrane As Well As To The Cis-Golgi In Fibroblasts |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-18 antibodyAnti-RAB18 antibody |
Information sourced from Uniprot.org