| Post Translational Modifications | Phosphorylation of Ser-106 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2. |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB12 may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy. |
| Protein Name | Ras-Related Protein Rab-12 |
| Database Links | Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Recycling Endosome MembraneLipid-AnchorCytoplasmic SideLysosome MembraneGolgi Apparatus MembraneCytoplasmic VesicleAutophagosome |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-12 antibodyAnti-RAB12 antibody |
Information sourced from Uniprot.org
