| Function | Downstream effector molecule for Rab11 GTPase which is involved in endocytic trafficking, cytokinesis and intracellular ciliogenesis by participating in membrane delivery. Recruited by Rab11 to endosomes where it links Rab11 to dynein motor complex. The functional Rab11-RAB11FIP3-dynein complex regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endocytic recycling compartment (ERC) during interphase of cell cycle. Facilitates the interaction between dynein and dynactin and activates dynein processivity. Binding with ASAP1 is needed to regulate the pericentrosomal localization of recycling endosomes. The Rab11-RAB11FIP3 complex is also implicated in the transport during telophase of vesicles derived from recycling endosomes to the cleavage furrow via centrosome-anchored microtubules, where the vesicles function to deliver membrane during late cytokinesis and abscission. The recruitment of Rab11-RAB11FIP3-containing endosomes to the cleavage furrow and tethering to the midbody is co-mediated by RAB11FIP3 interaction with ARF6-exocyst and RACGAP1-MKLP1 tethering complexes. Also involved in the Rab11-Rabin8-Rab8 ciliogenesis cascade by facilitating the orderly assembly of a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which directs preciliary vesicle trafficking to mother centriole and ciliogenesis initiation. Also promotes the activity of Rab11 and ASAP1 in the ARF4-dependent Golgi-to-cilia transport of the sensory receptor rhodopsin. Competes with WDR44 for binding to Rab11, which controls intracellular ciliogenesis pathway. May play a role in breast cancer cell motility by regulating actin cytoskeleton. |
| Protein Name | Rab11 Family-Interacting Protein 3Fip3Fip3-Rab11Rab11-Fip3Arfophilin-1Ef Hands-Containing Rab-Interacting ProteinEferinMu-Mb-17.148 |
| Database Links | Reactome: R-HSA-5620916 |
| Cellular Localisation | Endosome MembraneRecycling Endosome MembranePeripheral Membrane ProteinCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCleavage FurrowMidbodyGolgi Apparatus MembraneGolgi ApparatusTrans-Golgi Network MembraneDuring InterphaseLocalized In Vesicles Continuously Moving From Peripheral Sorting Endosomes In The Cell Towards The Pericentrosomal Endosomal Recycling Compartment (Erc)In Early Mitosis Remains Diffuse And Distributed Through The CellThe Onset Of Anaphase Sequesters These Vesicles To The Centrosomes At The Opposite Poles Of The CellDuring Telophase These Vesicles Move From The CentrosomesTo The FurrowAnd Then To The Midbody To Aid In AbscissionInteraction With Rab11 Mediates Localization To EndosomesInteraction With Arf6 Mediates Localization To The MidbodyLocalized To The Golgi And Tgn When Interacting With Rho In PhotoreceptorsLocalized To Rhodopsin Transport Carriers When Interacting With Rab11a And Asap1 In Photoreceptors |
| Alternative Antibody Names | Anti-Rab11 Family-Interacting Protein 3 antibodyAnti-Fip3 antibodyAnti-Fip3-Rab11 antibodyAnti-Rab11-Fip3 antibodyAnti-Arfophilin-1 antibodyAnti-Ef Hands-Containing Rab-Interacting Protein antibodyAnti-Eferin antibodyAnti-Mu-Mb-17.148 antibodyAnti-RAB11FIP3 antibodyAnti-ARFO1 antibodyAnti-KIAA0665 antibody |
Information sourced from Uniprot.org
