| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Pyrin and HIN domain-containing protein 1 (338-388 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PYHIN1 |
| Gene ID: | 149628 |
| Uniprot ID: | IFIX_HUMAN |
| Immunogen Region: | 338-388 aa |
| Specificity: | This antibody detects endogenous levels of IFIX at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human IFIX at the amino acid range 338-388 |
| Function | Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells. |
| Protein Name | Pyrin And Hin Domain-Containing Protein 1Interferon-Inducible Protein X |
| Cellular Localisation | Isoform 1: NucleusNucleoplasmIsoform 3: NucleusIsoform 5: NucleusNucleus Speckle |
| Alternative Antibody Names | Anti-Pyrin And Hin Domain-Containing Protein 1 antibodyAnti-Interferon-Inducible Protein X antibodyAnti-PYHIN1 antibodyAnti-IFIX antibody |
Information sourced from Uniprot.org