| Host: | Rabbit |
| Applications: | IHC/IF |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Pyrin domain-containing protein 1 (25-75 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC-P 1:50-200IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PYDC1 |
| Gene ID: | 260434 |
| Uniprot ID: | PYDC1_HUMAN |
| Immunogen Region: | 25-75 aa |
| Specificity: | This antibody detects endogenous levels of PYDC1 at Human |
| Immunogen: | Synthesized peptide derived from the human PYDC1 at the amino acid range 25-75 |
| Post Translational Modifications | Phosphorylated. |
| Function | Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS. |
| Protein Name | Pyrin Domain-Containing Protein 1Paad-Only Protein 1Pyrin-Only Protein 1Cellular Pop1Cpop1 |
| Cellular Localisation | CytoplasmRecruited To Specks Formed By Pycard Within The Cytoplasm |
| Alternative Antibody Names | Anti-Pyrin Domain-Containing Protein 1 antibodyAnti-Paad-Only Protein 1 antibodyAnti-Pyrin-Only Protein 1 antibodyAnti-Cellular Pop1 antibodyAnti-Cpop1 antibodyAnti-PYDC1 antibodyAnti-ASC2 antibodyAnti-ASCI antibodyAnti-POP1 antibodyAnti-PYC1 antibody |
Information sourced from Uniprot.org