Anti-PWWP2B antibody (268-317 aa) (STJ95274)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human PWWP2B at the amino acid range 268-317
General Information
| Short Description | Rabbit polyclonal anti-PWWP domain-containing protein 2B (268-317 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PWWP2B |
| Gene ID | 170394 |
| Uniprot ID | PWP2B_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human PWWP2B at the amino acid range 268-317 |
| Immunogen Region | 268-317 aa |
| Specificity | PWWP2B Polyclonal Antibody detects endogenous levels of PWWP2B protein. |
Additional Info
| Function | Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes. Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z. Plays a role in facilitating transcriptional elongation through regulation of histone acetylation. Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression. |
| Protein Name | Pwwp Domain-Containing Protein 2b |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Pwwp Domain-Containing Protein 2b antibodyAnti-PWWP2B antibodyAnti-PWWP2 antibody |
Information sourced from Uniprot.org