| Short Description : | Rabbit monoclonal anti-PUMA for use in WB, IHC-P, ICC, IF and FC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/ICC/IF/FC |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | R01-3K2 |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Purification: | Affinity Chromatography |
| Dilution Range: | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200FC 1:50-1:100 |
| Formulation: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | BBC3 |
| Gene ID: | 27113 |
| Uniprot ID: | BBC3_HUMAN |
| Immunogen: | A synthesized peptide derived from human PUMA |
| Tissue Specificity | Ubiquitously expressed. |
| Function | Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis. Regulates ER stress-induced neuronal apoptosis. |
| Protein Name | Bcl-2-Binding Component 3 - Isoforms 1/2Jfy-1P53 Up-Regulated Modulator Of Apoptosis |
| Database Links | Reactome: R-HSA-111453Reactome: R-HSA-139915Reactome: R-HSA-6803204Reactome: R-HSA-9614657 |
| Cellular Localisation | MitochondrionLocalized To The Mitochondria In Order To Induce Cytochrome C Release |
| Alternative Antibody Names | Anti-Bcl-2-Binding Component 3 - Isoforms 1/2 antibodyAnti-Jfy-1 antibodyAnti-P53 Up-Regulated Modulator Of Apoptosis antibodyAnti-BBC3 antibodyAnti-PUMA antibody |
Information sourced from Uniprot.org
