| Post Translational Modifications | The extracellular domain is proteolytically processed through cleavage within the fibronectin type-III 4 domain. In addition to the 190 kDa full-length protein, proteolytic products of 100 kDa, 80 kDa and 73 kDa are observed. N-glycosylated. Phosphorylated on tyrosine residues upon activation of KIT with stem cell factor (SCF). The 73 kDa proteolytic product is not phosphorylated. |
| Function | Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis. |
| Protein Name | Receptor-Type Tyrosine-Protein Phosphatase UR-Ptp-UPancreatic Carcinoma Phosphatase 2Pcp-2Protein-Tyrosine Phosphatase JPtp-JHptp-JProtein-Tyrosine Phosphatase PiPtp PiProtein-Tyrosine Phosphatase Receptor OmicronPtp-RoReceptor-Type Protein-Tyrosine Phosphatase PsiR-Ptp-Psi |
| Database Links | Reactome: R-HSA-1433557 |
| Cellular Localisation | Cell JunctionCell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Receptor-Type Tyrosine-Protein Phosphatase U antibodyAnti-R-Ptp-U antibodyAnti-Pancreatic Carcinoma Phosphatase 2 antibodyAnti-Pcp-2 antibodyAnti-Protein-Tyrosine Phosphatase J antibodyAnti-Ptp-J antibodyAnti-Hptp-J antibodyAnti-Protein-Tyrosine Phosphatase Pi antibodyAnti-Ptp Pi antibodyAnti-Protein-Tyrosine Phosphatase Receptor Omicron antibodyAnti-Ptp-Ro antibodyAnti-Receptor-Type Protein-Tyrosine Phosphatase Psi antibodyAnti-R-Ptp-Psi antibodyAnti-PTPRU antibodyAnti-FMI antibodyAnti-PCP2 antibodyAnti-PTPRO antibody |
Information sourced from Uniprot.org
