Host: | Rabbit |
Applications: | WB/ELISA |
Reactivity: | Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality: | Monoclonal |
Clone ID: | S4146RM |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | PTPRR |
Gene ID: | 5801 |
Uniprot ID: | PTPRR_HUMAN |
Immunogen Region: | 1-100 |
Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PTPRR (Q15256). |
Immunogen Sequence: | MRRAVCFPALCLLLNLHAAG CFSGNNDHFLAINQKKSGKP VFIYKHSQDIEKSLDIAPQK IYRHSYHSSSEAQVSKRHQI VNSAFPRPAYDPSLNLLAMD |
Tissue Specificity | Detected in cerebrospinal fluid (at protein level). Expressed in brain, placenta, small intestine, stomach, uterus and weakly in the prostate. Isoform alpha has been observed only in the brain. Isoform gamma is expressed in brain, placenta and uterus. Isoform delta is expressed in brain, kidney, placenta, prostate, small intestine and uterus. |
Function | Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus. |
Protein Name | Receptor-Type Tyrosine-Protein Phosphatase R R-Ptp-R Ch-1ptpase Nc-Ptpcom1 Protein-Tyrosine Phosphatase Pcptp1 |
Cellular Localisation | Secreted Isoform Alpha: Cell Membrane Single-Pass Type I Membrane Protein Isoform Delta: Cytoplasm Perinuclear Region Locates To The Perinuclear Areas Within The Cytoplasm Isoform Gamma: Cytoplasm |
Alternative Antibody Names | Anti-Receptor-Type Tyrosine-Protein Phosphatase R antibody Anti-R-Ptp-R antibody Anti-Ch-1ptpase antibody Anti-Nc-Ptpcom1 antibody Anti-Protein-Tyrosine Phosphatase Pcptp1 antibody Anti-PTPRR antibody Anti-ECPTP antibody Anti-PTPRQ antibody |
Information sourced from Uniprot.org