Anti-PTPRA antibody (650-700) {Biotin} (STJ502721)

SKU:
STJ502721-100

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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PTPRA (650-700) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5-1.5 µg/µl
Dilution Range: WB: 1:2, 500-1:5, 000
ELISA: 1:50, 000
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PTPRA
Gene ID: 5786
Uniprot ID: PTPRA_HUMAN
Immunogen Region: 650-700
Immunogen: Synthetic peptide taken within amino acid region 650-700 on human Receptor-type tyrosine-protein phosphatase Alpha protein.
Post Translational Modifications Integrin binding to extracellular matrix induces phosphorylation at Tyr-798 which induces PTPRA localization and recruitment of BCAR3, BCAR1 and CRK to focal adhesions.
Function Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation. Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42.
Protein Name Receptor-Type Tyrosine-Protein Phosphatase Alpha
Protein-Tyrosine Phosphatase Alpha
R-Ptp-Alpha
Database Links Reactome: R-HSA-375165
Reactome: R-HSA-5673001
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Focal Adhesion
Localizes To Focal Adhesion Sites Following Integrin Engagement
Alternative Antibody Names Anti-Receptor-Type Tyrosine-Protein Phosphatase Alpha antibody
Anti-Protein-Tyrosine Phosphatase Alpha antibody
Anti-R-Ptp-Alpha antibody
Anti-PTPRA antibody
Anti-PTPA antibody
Anti-PTPRL2 antibody

Information sourced from Uniprot.org

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