Anti-PTPN23 antibody (1230-1450) (STJ25227)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PTPN23 (1230-1450) antibody for use in WB, IHC-P and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PTPN23 |
| Gene ID | 25930 |
| Uniprot ID | PTN23_HUMAN |
| Immunogen Region | 1230-1450 |
| Immunogen Sequence | DSNRVVLRSGKDDYINASCV EGLSPYCPPLVATQAPLPGT AADFWLMVHEQKVSVIVMLV SEAEMEKQKVARYFPTERGQ PMVHGALSLALSSVRSTETH VERVLSLQFRDQSLKRSLVH LHFPTWPELGLPDSPSNLLR FIQEVHAHYLHQRPLHTPII VHCSSGVGRTGAFALLYAAV QEVEAGNGIPELPQLVRRMR QQRKHMLQEKLHLRFCYEAV V |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1230-1450 of human PTPN23 (NP_056281.1). |
Additional Info
| Function | Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis. |
| Protein Name | Tyrosine-Protein Phosphatase Non-Receptor Type 23His Domain-Containing Protein Tyrosine PhosphataseHd-PtpProtein Tyrosine Phosphatase Td14Ptp-Td14 |
| Database Links | Reactome: R-HSA-9008059 |
| Cellular Localisation | NucleusCytoplasmCytoplasmic VesicleEndosomeCytoskeletonCilium Basal BodyEarly Endosome |
| Alternative Antibody Names | Anti-Tyrosine-Protein Phosphatase Non-Receptor Type 23 antibodyAnti-His Domain-Containing Protein Tyrosine Phosphatase antibodyAnti-Hd-Ptp antibodyAnti-Protein Tyrosine Phosphatase Td14 antibodyAnti-Ptp-Td14 antibodyAnti-PTPN23 antibodyAnti-KIAA1471 antibody |
Information sourced from Uniprot.org