| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PTPN23 |
| Gene ID: | 25930 |
| Uniprot ID: | PTN23_HUMAN |
| Immunogen Region: | 1230-1450 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1230-1450 of human PTPN23 (NP_056281.1). |
| Immunogen Sequence: | DSNRVVLRSGKDDYINASCV EGLSPYCPPLVATQAPLPGT AADFWLMVHEQKVSVIVMLV SEAEMEKQKVARYFPTERGQ PMVHGALSLALSSVRSTETH VERVLSLQFRDQSLKRSLVH LHFPTWPELGLPDSPSNLLR FIQEVHAHYLHQRPLHTPII VHCSSGVGRTGAFALLYAAV QEVEAGNGIPELPQLVRRMR QQRKHMLQEKLHLRFCYEAV V |
| Function | Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis. |
| Protein Name | Tyrosine-Protein Phosphatase Non-Receptor Type 23His Domain-Containing Protein Tyrosine PhosphataseHd-PtpProtein Tyrosine Phosphatase Td14Ptp-Td14 |
| Database Links | Reactome: R-HSA-9008059 |
| Cellular Localisation | NucleusCytoplasmCytoplasmic VesicleEndosomeCytoskeletonCilium Basal BodyEarly Endosome |
| Alternative Antibody Names | Anti-Tyrosine-Protein Phosphatase Non-Receptor Type 23 antibodyAnti-His Domain-Containing Protein Tyrosine Phosphatase antibodyAnti-Hd-Ptp antibodyAnti-Protein Tyrosine Phosphatase Td14 antibodyAnti-Ptp-Td14 antibodyAnti-PTPN23 antibodyAnti-KIAA1471 antibody |
Information sourced from Uniprot.org