• Immunohistochemical analysis of paraffin-embedded human Gastric adenocarcinoma. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).

Anti-PTPN22 antibody (N-Term) (STJ95266)

SKU:
STJ95266

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Tyrosine-protein phosphatase non-receptor type 22 (N-Term) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-P 1:50-300
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PTPN22
Gene ID: 26191
Uniprot ID: PTN22_HUMAN
Immunogen Region: N-Term
Specificity: PTP22 Polyclonal Antibody detects endogenous levels of PTP22 protein.
Immunogen: Synthesized peptide derived from the N-terminal region of human PTP22.
Post Translational Modifications Phosphorylation on Ser-35 by PKC/PRKCD abrogates its ability to dephosphorylate and inactivate the SRC family kinases.
Function Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2. Positively regulates toll-like receptor (TLR)-induced type 1 interferon production. Promotes host antiviral responses mediated by type 1 interferon. Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy. Acts as an activator of NLRP3 inflammasome assembly by mediating dephosphorylation of 'Tyr-861' of NLRP3. Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide).
Protein Name Tyrosine-Protein Phosphatase Non-Receptor Type 22
Hematopoietic Cell Protein-Tyrosine Phosphatase 70z-Pep
Lymphoid Phosphatase
Lyp
Pest-Domain Phosphatase
Pep
Database Links Reactome: R-HSA-202427
Reactome: R-HSA-202430
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Tyrosine-Protein Phosphatase Non-Receptor Type 22 antibody
Anti-Hematopoietic Cell Protein-Tyrosine Phosphatase 70z-Pep antibody
Anti-Lymphoid Phosphatase antibody
Anti-Lyp antibody
Anti-Pest-Domain Phosphatase antibody
Anti-Pep antibody
Anti-PTPN22 antibody
Anti-PTPN8 antibody

Information sourced from Uniprot.org

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