| Tissue Specificity | Expressed in bone marrow, B and T-cells, PBMCs, natural killer cells, monocytes, dendritic cells and neutrophils. Both isoform 1 and 4 are predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells. |
| Post Translational Modifications | Phosphorylation on Ser-35 by PKC/PRKCD abrogates its ability to dephosphorylate and inactivate the SRC family kinases. |
| Function | Acts as a negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2. Positively regulates toll-like receptor (TLR)-induced type 1 interferon production. Promotes host antiviral responses mediated by type 1 interferon. Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy. Acts as an activator of NLRP3 inflammasome assembly by mediating dephosphorylation of 'Tyr-861' of NLRP3. Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide). |
| Protein Name | Tyrosine-Protein Phosphatase Non-Receptor Type 22Hematopoietic Cell Protein-Tyrosine Phosphatase 70z-PepLymphoid PhosphataseLypPest-Domain PhosphatasePep |
| Database Links | Reactome: R-HSA-202427Reactome: R-HSA-202430 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Tyrosine-Protein Phosphatase Non-Receptor Type 22 antibodyAnti-Hematopoietic Cell Protein-Tyrosine Phosphatase 70z-Pep antibodyAnti-Lymphoid Phosphatase antibodyAnti-Lyp antibodyAnti-Pest-Domain Phosphatase antibodyAnti-Pep antibodyAnti-PTPN22 antibodyAnti-PTPN8 antibody |
Information sourced from Uniprot.org
