| Short Description : | Rabbit polyclonal PTPN13 (250-500) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:2000-1:6000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PTPN13 |
| Gene ID: | 5783 |
| Uniprot ID: | PTN13_HUMAN |
| Immunogen Region: | 250-500 |
| Immunogen Sequence: | QDENYFKDILSDNSGREDSE NTFSPYQFKTSGPEKKPIPG IDVLSKKKIWASSMDLLCTA DRDFSSGETATYRRCHPEAV TVRTSTTPRKKEARYSDGSI ALDIFGPQKMDPIYHTRELP TSSAISSALDRIRERQKKLQ VLREAMNVEEPVRRYKTYHG DVFSTSSESPSIISSESDFR QVRRSEASKRFESSSGLPGV DETLSQGQSQRPSRQYETPF EGNLINQEIMLKRQEEELM |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-500 of human PTPN13 (NP_542416.1). |
| Tissue Specificity | Expressed in keratinocytes (at protein level). Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in lung, kidney and fetal brain. |
| Function | Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2. |
| Protein Name | Tyrosine-Protein Phosphatase Non-Receptor Type 13Fas-Associated Protein-Tyrosine Phosphatase 1Fap-1Ptp-BasProtein-Tyrosine Phosphatase 1ePtp-E1Hptpe1Protein-Tyrosine Phosphatase Ptpl1 |
| Database Links | Reactome: R-HSA-1660499Reactome: R-HSA-9008059Reactome: R-HSA-9696264Reactome: R-HSA-9696270Reactome: R-HSA-9696273 |
| Cellular Localisation | CytoplasmCytoskeletonNucleusCell ProjectionLamellipodiumColocalizes With F-ActinColocalizes With Pkn2 In Lamellipodia-Like StructureRegions Of Large Actin Turnover |
| Alternative Antibody Names | Anti-Tyrosine-Protein Phosphatase Non-Receptor Type 13 antibodyAnti-Fas-Associated Protein-Tyrosine Phosphatase 1 antibodyAnti-Fap-1 antibodyAnti-Ptp-Bas antibodyAnti-Protein-Tyrosine Phosphatase 1e antibodyAnti-Ptp-E1 antibodyAnti-Hptpe1 antibodyAnti-Protein-Tyrosine Phosphatase Ptpl1 antibodyAnti-PTPN13 antibodyAnti-PNP1 antibodyAnti-PTP1E antibodyAnti-PTPL1 antibody |
Information sourced from Uniprot.org
