| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000 IHC-P:1:50-1:100 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PTPN11 |
| Gene ID: | 5781 |
| Uniprot ID: | PTN11_HUMAN |
| Immunogen Region: | 514-593 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 514-593 of human SHP2 (NP_002825.3). |
| Immunogen Sequence: | IYMAVQHYIETLQRRIEEEQ KSKRKGHEYTNIKYSLADQT SGDQSPLPPCTPTPPCAEMR EDSARVYENVGLMQQQKSFR |
| Tissue Specificity | Widely expressed, with highest levels in heart, brain, and skeletal muscle. |
| Post Translational Modifications | Phosphorylated on Tyr-542 and Tyr-580 upon receptor protein tyrosine kinase activation.which creates a binding site for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3. Phosphorylated upon activation of the receptor-type kinase PDGFRA. Phosphorylated by activated PDGFRB. |
| Function | Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity. Dephosphorylates CDC73. Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification. Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L. |
| Protein Name | Tyrosine-Protein Phosphatase Non-Receptor Type 11 Protein-Tyrosine Phosphatase 1d Ptp-1d Protein-Tyrosine Phosphatase 2c Ptp-2c Sh-Ptp2 Shp-2 Shp2 Sh-Ptp3 |
| Database Links | Reactome: R-HSA-1059683 Reactome: R-HSA-109704 Reactome: R-HSA-110056 Reactome: R-HSA-112411 Reactome: R-HSA-114604 Reactome: R-HSA-1170546 Reactome: R-HSA-1257604 Reactome: R-HSA-1295596 Reactome: R-HSA-1433557 Reactome: R-HSA-180292 Reactome: R-HSA-186763 Reactome: R-HSA-210990 Reactome: R-HSA-210993 Reactome: R-HSA-2219530 Reactome: R-HSA-2586552 Reactome: R-HSA-388841 Reactome: R-HSA-389513 Reactome: R-HSA-389948 Reactome: R-HSA-391160 Reactome: R-HSA-418886 Reactome: R-HSA-432142 Reactome: R-HSA-512988 Reactome: R-HSA-5654689 Reactome: R-HSA-5654693 Reactome: R-HSA-5654695 Reactome: R-HSA-5654700 Reactome: R-HSA-5654706 Reactome: R-HSA-5654710 Reactome: R-HSA-5654712 Reactome: R-HSA-5654720 Reactome: R-HSA-5654726 Reactome: R-HSA-5654727 Reactome: R-HSA-5654732 Reactome: R-HSA-5654733 Reactome: R-HSA-6811558 Reactome: R-HSA-877312 Reactome: R-HSA-8853659 Reactome: R-HSA-8854691 Reactome: R-HSA-8865999 Reactome: R-HSA-8934593 Reactome: R-HSA-9008059 Reactome: R-HSA-9028731 Reactome: R-HSA-909733 Reactome: R-HSA-912694 Reactome: R-HSA-936964 Reactome: R-HSA-9607240 Reactome: R-HSA-9645135 Reactome: R-HSA-9674555 Reactome: R-HSA-9680350 Reactome: R-HSA-9702518 Reactome: R-HSA-9703648 Reactome: R-HSA-9705671 |
| Cellular Localisation | Cytoplasm Nucleus |
| Alternative Antibody Names | Anti-Tyrosine-Protein Phosphatase Non-Receptor Type 11 antibody Anti-Protein-Tyrosine Phosphatase 1d antibody Anti-Ptp-1d antibody Anti-Protein-Tyrosine Phosphatase 2c antibody Anti-Ptp-2c antibody Anti-Sh-Ptp2 antibody Anti-Shp-2 antibody Anti-Shp2 antibody Anti-Sh-Ptp3 antibody Anti-PTPN11 antibody Anti-PTP2C antibody Anti-SHPTP2 antibody |
Information sourced from Uniprot.org