Anti-PTK7/CCK-4 antibody [SAA0144] {FITC} (STJA0028580)
SPECIFICATIONS
ClonalityMonoclonal
HostHuman
ConjugationFITC
IsotypeIgG1k
General Information
| Short Description | Human monoclonal Inactive Tyrosine-Protein Kinase 7 antibody for use in ELISA and FC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/FC |
| Host | Human |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA0144 |
| Isotype | IgG1k |
| Conjugation | FITC |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Formulation | PBS pH 7.4, 50% glycerol, 0.05% proclin300 |
| Storage Instruction | Store at 4°C for 12 months. Protect from light. Do not freeze. |
Target Information
| Gene Symbol | PTK7 |
| Gene ID | 5754 |
| Uniprot ID | PTK7_HUMAN |
Additional Info
| Post Translational Modifications | MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway. |
| Function | Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. |
| Protein Name | Inactive Tyrosine-Protein Kinase 7Colon Carcinoma Kinase 4Cck-4Protein-Tyrosine Kinase 7Pseudo Tyrosine Kinase Receptor 7Tyrosine-Protein Kinase-Like 7 |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCell JunctionColocalizes With Mmp14 At Cell JunctionsAlso Localizes At The Leading Edge Of Migrating Cells |
| Alternative Antibody Names | Anti-Inactive Tyrosine-Protein Kinase 7 antibodyAnti-Colon Carcinoma Kinase 4 antibodyAnti-Cck-4 antibodyAnti-Protein-Tyrosine Kinase 7 antibodyAnti-Pseudo Tyrosine Kinase Receptor 7 antibodyAnti-Tyrosine-Protein Kinase-Like 7 antibodyAnti-PTK7 antibodyAnti-CCK4 antibody |
Information sourced from Uniprot.org