Immunohistochemistry analysis of paraffin-embedded human kidney tissues with DAB staining using PTH/PTHrP-R monoclonal antibody.

Anti-PTH1R antibody [4D2] (STJ98344)

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STJ98344
€178.80 - €432.00
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Short Description :Mouse monoclonal anti-Parathyroid hormone/parathyroid hormone-related peptide receptor for use in WB, IHC, IF and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:WB/IHC/IF/ELISA
Host:Mouse
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :4D2
Isotype:IgG1
Conjugation:Unconjugated
Purification:Affinity purification
Dilution Range:WB 1:500-1:2000
IHC 1:200-1:1000
IF 1:200-1:1000
ELISA 1:10000
Formulation:Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol.
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol:PTH1R
Gene ID:5745
Uniprot ID:PTH1R_HUMAN
Immunogen:Purified recombinant fragment of human PTH/PTHrP-R expressed in E. Coli.
Specificity:PTH/PTHrP-R Monoclonal Antibody detects endogenous levels of PTH/PTHrP-R protein.
Post Translational Modifications N-glycosylated.
Function G-protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. PTHLH dissociates from PTH1R more rapidly than PTH.as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH.
Protein Name Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor
Pth/Pthrp Type I Receptor
Pth/Pthr Receptor
Parathyroid Hormone 1 Receptor
Pth1 Receptor
Database Links Reactome: R-HSA-373080
Reactome: R-HSA-418555
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor antibody
Anti-Pth/Pthrp Type I Receptor antibody
Anti-Pth/Pthr Receptor antibody
Anti-Parathyroid Hormone 1 Receptor antibody
Anti-Pth1 Receptor antibody
Anti-PTH1R antibody
Anti-PTHR antibody
Anti-PTHR1 antibody

Information sourced from Uniprot.org

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