| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-PTGR1 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-0.3-1µg/mlELISA-antibody detection limit dilution 1:128000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
PTGR1 |
| Gene ID: |
22949 |
| Uniprot ID: |
PTGR1_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_036344.2; NP_001139581.1 |
| Specificity: |
This antibody is expected to recognize both reported isoforms (NP_036344.2; NP_001139581.1). Reported variants represent identical protein: NP_036344.2, NP_001139580.1. |
| Immunogen Sequence: |
PTNSDFELKTAELP |
| Function | NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha. Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites. Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site. May play a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one. May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles. |
| Protein Name | Prostaglandin Reductase 1Prg-115-Oxoprostaglandin 13-ReductaseDithiolethione-Inducible Gene 1 ProteinD3t-Inducible Gene 1 ProteinDig-1Leukotriene B4 12-HydroxydehydrogenaseNad(Ph-Dependent Alkenal/One Oxidoreductase |
| Database Links | Reactome: R-HSA-2142691Reactome: R-HSA-2142700 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Prostaglandin Reductase 1 antibodyAnti-Prg-1 antibodyAnti-15-Oxoprostaglandin 13-Reductase antibodyAnti-Dithiolethione-Inducible Gene 1 Protein antibodyAnti-D3t-Inducible Gene 1 Protein antibodyAnti-Dig-1 antibodyAnti-Leukotriene B4 12-Hydroxydehydrogenase antibodyAnti-Nad(Ph-Dependent Alkenal/One Oxidoreductase antibodyAnti-PTGR1 antibodyAnti-LTB4DH antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
