Anti-PTGIS antibody (C-Term) (STJ95055)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the C-terminal region of human PGI2 synthase.
General Information
| Short Description | Rabbit polyclonal anti-Prostacyclin synthase (C-Term) for use in WB, ELISA and IHC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PTGIS |
| Gene ID | 5740 |
| Uniprot ID | PTGIS_HUMAN |
| Immunogen | Synthesized peptide derived from the C-terminal region of human PGI2 synthase. |
| Immunogen Region | C-Term |
| Specificity | PGI2 synthase Polyclonal Antibody detects endogenous levels of PGI2 synthase protein. |
Additional Info
| Function | Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation. Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE). |
| Protein Name | Prostacyclin SynthaseHydroperoxy Icosatetraenoate DehydrataseProstaglandin I2 Synthase |
| Database Links | Reactome: R-HSA-197264Reactome: R-HSA-211979Reactome: R-HSA-2162123 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Prostacyclin Synthase antibodyAnti-Hydroperoxy Icosatetraenoate Dehydratase antibodyAnti-Prostaglandin I2 Synthase antibodyAnti-PTGIS antibodyAnti-CYP8 antibodyAnti-CYP8A1 antibody |
Information sourced from Uniprot.org