| Host: | Rabbit |
| Applications: | WB/ELISA/IHC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Prostacyclin synthase (C-Term) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PTGIS |
| Gene ID: | 5740 |
| Uniprot ID: | PTGIS_HUMAN |
| Immunogen Region: | C-Term |
| Specificity: | PGI2 synthase Polyclonal Antibody detects endogenous levels of PGI2 synthase protein. |
| Immunogen: | Synthesized peptide derived from the C-terminal region of human PGI2 synthase. |
| Function | Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation. Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE). |
| Protein Name | Prostacyclin SynthaseHydroperoxy Icosatetraenoate DehydrataseProstaglandin I2 Synthase |
| Database Links | Reactome: R-HSA-197264Reactome: R-HSA-211979Reactome: R-HSA-2162123 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Prostacyclin Synthase antibodyAnti-Hydroperoxy Icosatetraenoate Dehydratase antibodyAnti-Prostaglandin I2 Synthase antibodyAnti-PTGIS antibodyAnti-CYP8 antibodyAnti-CYP8A1 antibody |
Information sourced from Uniprot.org