| Tissue Specificity | Widely expressed.particularly abundant in ovary, heart, skeletal muscle, lung and prostate. |
| Function | Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation. Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE). |
| Protein Name | Prostacyclin SynthaseHydroperoxy Icosatetraenoate DehydrataseProstaglandin I2 Synthase |
| Database Links | Reactome: R-HSA-197264Reactome: R-HSA-211979Reactome: R-HSA-2162123 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Prostacyclin Synthase antibodyAnti-Hydroperoxy Icosatetraenoate Dehydratase antibodyAnti-Prostaglandin I2 Synthase antibodyAnti-PTGIS antibodyAnti-CYP8 antibodyAnti-CYP8A1 antibody |
Information sourced from Uniprot.org
