| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
PTGIS |
| Gene ID: |
5740 |
| Uniprot ID: |
PTGIS_HUMAN |
| Immunogen Region: |
151-500 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 151-500 of human PTGIS (NP_000952.1). |
| Immunogen Sequence: |
DATEAGSGWHEMGLLDFSYS FLLRAGYLTLYGIEALPRTH ESQAQDRVHSADVFHTFRQL DRLLPKLARGSLSVGDKDHM CSVKSRLWKLLSPARLARRA HRSKWLESYLLHLEEMGVSE EMQARALVLQLWATQGNMGP AAFWLLLFLLKNPEALAAVR GELESILWQAEQPVSQTTTL PQKVLDSTPVLDSVLSESLR LTAAPFITREVVVDLAMPMA DGREFNLRRGDRLLLFPFL |
| Tissue Specificity | Widely expressed.particularly abundant in ovary, heart, skeletal muscle, lung and prostate. |
| Function | Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation. Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE). |
| Protein Name | Prostacyclin SynthaseHydroperoxy Icosatetraenoate DehydrataseProstaglandin I2 Synthase |
| Database Links | Reactome: R-HSA-197264Reactome: R-HSA-211979Reactome: R-HSA-2162123 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Prostacyclin Synthase antibodyAnti-Hydroperoxy Icosatetraenoate Dehydratase antibodyAnti-Prostaglandin I2 Synthase antibodyAnti-PTGIS antibodyAnti-CYP8 antibodyAnti-CYP8A1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
