| Function | Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli. Plays a key role in inflammation response, fever and pain. Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively. |
| Protein Name | Prostaglandin E SynthaseGlutathione Peroxidase PtgesGlutathione Transferase PtgesMicrosomal Glutathione S-Transferase 1-Like 1Mgst1-L1Microsomal Prostaglandin E Synthase 1Mpges-1P53-Induced Gene 12 Protein |
| Database Links | Reactome: R-HSA-2162123 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCytoplasmPerinuclear RegionColocalizes With Ptgs1/Cox-1 And Ptgs2/Cox-2 In The Perinuclear Compartment |
| Alternative Antibody Names | Anti-Prostaglandin E Synthase antibodyAnti-Glutathione Peroxidase Ptges antibodyAnti-Glutathione Transferase Ptges antibodyAnti-Microsomal Glutathione S-Transferase 1-Like 1 antibodyAnti-Mgst1-L1 antibodyAnti-Microsomal Prostaglandin E Synthase 1 antibodyAnti-Mpges-1 antibodyAnti-P53-Induced Gene 12 Protein antibodyAnti-PTGES antibodyAnti-MGST1L1 antibodyAnti-MPGES1 antibodyAnti-PGES antibodyAnti-PIG12 antibody |
Information sourced from Uniprot.org
