| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-Ptgds-Mouse (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-0.1-0.3µg/mlELISA-antibody detection limit dilution 1:8000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_032989.2 |
| Immunogen Sequence: |
YSRTQTLKDELKEK |
| Function | Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR. |
| Protein Name | Prostaglandin-H2 D-IsomeraseGlutathione-Independent Pgd SynthaseLipocalin-Type Prostaglandin-D SynthaseProstaglandin-D2 SynthaseL-PgdsPgd2 SynthasePgds2 |
| Database Links | Reactome: R-MMU-2162123 |
| Cellular Localisation | Rough Endoplasmic ReticulumNucleus MembraneGolgi ApparatusCytoplasmPerinuclear RegionSecretedDetected On Rough Endoplasmic Reticulum Of Arachnoid And Menigioma CellsLocalized To The Nuclear EnvelopeSecretory Vesicles And Spherical Cytoplasmic Structures In Arachnoid Trabecular CellsAnd To Circular Cytoplasmic Structures In Meningeal Macrophages And Perivascular Microglial CellsIn OligodendrocytesLocalized To The Rough Endoplasmic Reticulum And Nuclear EnvelopeIn Retinal Pigment Epithelial CellsLocalized To Distinct Cytoplasmic Domains Including The Perinuclear RegionAlso Secreted |
| Alternative Antibody Names | Anti-Prostaglandin-H2 D-Isomerase antibodyAnti-Glutathione-Independent Pgd Synthase antibodyAnti-Lipocalin-Type Prostaglandin-D Synthase antibodyAnti-Prostaglandin-D2 Synthase antibodyAnti-L-Pgds antibodyAnti-Pgd2 Synthase antibodyAnti-Pgds2 antibodyAnti-Ptgds antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
