| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IF/ICC:1:10-1:100 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PSMA1 |
| Gene ID: | 5682 |
| Uniprot ID: | PSA1_HUMAN |
| Immunogen Region: | 1-263 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-263 of human PSMA1 (NP_002777.1). |
| Immunogen Sequence: | MFRNQYDNDVTVWSPQGRIH QIEYAMEAVKQGSATVGLKS KTHAVLVALKRAQSELAAHQ KKILHVDNHIGISIAGLTAD ARLLCNFMRQECLDSRFVFD RPLPVSRLVSLIGSKTQIPT QRYGRRPYGVGLLIAGYDDM GPHIFQTCPSANYFDCRAMS IGARSQSARTYLERHMSEFM ECNLNELVKHGLRALRETLP AEQDLTTKNVSIGIVGKDLE FTIYDDDDVSPFLEGLEER |
| Function | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). |
| Protein Name | Proteasome Subunit Alpha Type-1 30 Kda Prosomal Protein Pros-30 Macropain Subunit C2 Multicatalytic Endopeptidase Complex Subunit C2 Proteasome Component C2 Proteasome Nu Chain Proteasome Subunit Alpha-6 Alpha-6 |
| Database Links | Reactome: R-HSA-1169091 Reactome: R-HSA-1234176 Reactome: R-HSA-1236974 Reactome: R-HSA-1236978 Reactome: R-HSA-174084 Reactome: R-HSA-174113 Reactome: R-HSA-174154 Reactome: R-HSA-174178 Reactome: R-HSA-174184 Reactome: R-HSA-180534 Reactome: R-HSA-180585 Reactome: R-HSA-187577 Reactome: R-HSA-195253 Reactome: R-HSA-202424 Reactome: R-HSA-211733 Reactome: R-HSA-2467813 Reactome: R-HSA-2871837 Reactome: R-HSA-349425 Reactome: R-HSA-350562 Reactome: R-HSA-382556 Reactome: R-HSA-450408 Reactome: R-HSA-4608870 Reactome: R-HSA-4641257 Reactome: R-HSA-4641258 Reactome: R-HSA-5358346 Reactome: R-HSA-5362768 Reactome: R-HSA-5607761 Reactome: R-HSA-5607764 Reactome: R-HSA-5610780 Reactome: R-HSA-5610783 Reactome: R-HSA-5610785 Reactome: R-HSA-5632684 Reactome: R-HSA-5658442 Reactome: R-HSA-5668541 Reactome: R-HSA-5676590 Reactome: R-HSA-5678895 Reactome: R-HSA-5687128 Reactome: R-HSA-5689603 Reactome: R-HSA-5689880 Reactome: R-HSA-68867 Reactome: R-HSA-68949 Reactome: R-HSA-69017 Reactome: R-HSA-69481 Reactome: R-HSA-69601 Reactome: R-HSA-75815 Reactome: R-HSA-8852276 Reactome: R-HSA-8854050 Reactome: R-HSA-8939236 Reactome: R-HSA-8939902 Reactome: R-HSA-8941858 Reactome: R-HSA-8948751 Reactome: R-HSA-8951664 Reactome: R-HSA-9010553 Reactome: R-HSA-9020702 Reactome: R-HSA-9604323 Reactome: R-HSA-9755511 Reactome: R-HSA-9762114 Reactome: R-HSA-9824272 Reactome: R-HSA-983168 |
| Cellular Localisation | Cytoplasm Nucleus Translocated From The Cytoplasm Into The Nucleus Following Interaction With Akirin2 Which Bridges The Proteasome With The Nuclear Import Receptor Ipo9 |
| Alternative Antibody Names | Anti-Proteasome Subunit Alpha Type-1 antibody Anti-30 Kda Prosomal Protein antibody Anti-Pros-30 antibody Anti-Macropain Subunit C2 antibody Anti-Multicatalytic Endopeptidase Complex Subunit C2 antibody Anti-Proteasome Component C2 antibody Anti-Proteasome Nu Chain antibody Anti-Proteasome Subunit Alpha-6 antibody Anti-Alpha-6 antibody Anti-PSMA1 antibody Anti-HC2 antibody Anti-NU antibody Anti-PROS30 antibody Anti-PSC2 antibody |
Information sourced from Uniprot.org