| Tissue Specificity | Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions. |
| Post Translational Modifications | Citrullinated by PADI4. |
| Function | Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. |
| Protein Name | Pc4 And Sfrs1-Interacting ProteinCll-Associated Antigen Kw-7Dense Fine Speckles 70 Kda ProteinDfs 70Lens Epithelium-Derived Growth FactorTranscriptional Coactivator P75/P52 |
| Database Links | Reactome: R-HSA-162592Reactome: R-HSA-164843Reactome: R-HSA-175567Reactome: R-HSA-177539Reactome: R-HSA-180689Reactome: R-HSA-180910Reactome: R-HSA-9772755 |
| Cellular Localisation | NucleusRemains Chromatin-Associated Throughout The Cell Cycle |
| Alternative Antibody Names | Anti-Pc4 And Sfrs1-Interacting Protein antibodyAnti-Cll-Associated Antigen Kw-7 antibodyAnti-Dense Fine Speckles 70 Kda Protein antibodyAnti-Dfs 70 antibodyAnti-Lens Epithelium-Derived Growth Factor antibodyAnti-Transcriptional Coactivator P75/P52 antibodyAnti-PSIP1 antibodyAnti-DFS70 antibodyAnti-LEDGF antibodyAnti-PSIP2 antibody |
Information sourced from Uniprot.org
