Anti-PSEN2/Presenilin-2 antibody [SAA1783] (STJA0020211)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal Presenilin-2 antibody for use in ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1783 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | PSEN2 |
| Gene ID | 5664 |
| Uniprot ID | PSN2_HUMAN |
Additional Info
| Post Translational Modifications | Heterogeneous proteolytic processing generates N-terminal and C-terminal fragments. Phosphorylated on serine residues. |
| Function | Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria. |
| Protein Name | Presenilin-2Ps-2Ad3lpAd5E5-1Stm-2 Cleaved Into - Presenilin-2 Ntf Subunit - Presenilin-2 Ctf Subunit |
| Database Links | Reactome: R-HSA-1251985Reactome: R-HSA-193692Reactome: R-HSA-205043Reactome: R-HSA-2122948Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-2979096Reactome: R-HSA-3928665Reactome: R-HSA-9013507Reactome: R-HSA-9013700Reactome: R-HSA-9017802Reactome: R-HSA-9839383 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Presenilin-2 antibodyAnti-Ps-2 antibodyAnti-Ad3lp antibodyAnti-Ad5 antibodyAnti-E5-1 antibodyAnti-Stm-2 Cleaved Into - Presenilin-2 Ntf Subunit - Presenilin-2 Ctf Subunit antibodyAnti-PSEN2 antibodyAnti-AD4 antibodyAnti-PS2 antibodyAnti-PSNL2 antibodyAnti-STM2 antibody |
Information sourced from Uniprot.org