| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PRX (1250-1350) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PRX |
| Gene ID: |
57716 |
| Uniprot ID: |
PRAX_HUMAN |
| Immunogen Region: |
1250-1350 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1250-1350 of human PRX (NP_870998.2). |
| Immunogen Sequence: |
LGARARVGGEGAEEQPPGAE RTFCLSLPDVELSPSGGNHA EYQVAEGEGEAGHKLKVRLP RFGLVRAKEGAEEGEKAKSP KLRLPRVGFSQSEMVTGEGS P |
| Tissue Specificity | Detected in spinal cord. Isoform 1 and isoform 2 are found in sciatic nerve and Schwann cells. |
| Function | Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells. Required for the maintenance of the peripheral myelin sheath that is essential for normal transmission of nerve impulses and normal perception of sensory stimuli. Required for normal transport of MBP mRNA from the perinuclear to the paranodal regions. Required for normal remyelination after nerve injury. Required for normal elongation of Schwann cells and normal length of the internodes between the nodes of Ranvier. The demyelinated nodes of Ranvier permit saltatory transmission of nerve impulses.shorter internodes cause slower transmission of nerve impulses. Required for the formation of appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane.the Schwann cell cytoplasm is restricted to regions between these appositions. Required for the formation of Cajal bands and of Schmidt-Lanterman incisures that correspond to short, cytoplasm-filled regions on myelinated nerves. Recruits DRP2 to the Schwann cell plasma membrane. Required for normal protein composition of the eye lens fiber cell plasma membrane and normal eye lens fiber cell morphology. |
| Protein Name | Periaxin |
| Database Links | Reactome: R-HSA-9619665 Q9BXM0-1 |
| Cellular Localisation | Isoform 1: Cell MembranePeripheral Membrane ProteinCytoplasmic SideNucleusCytoplasmDetected In The Schwann Cell Nucleus Prior To The Onset Of MyelinationDetected In Schwann Cells At Periaxonal Myelin MembranesAssociated With The Cell Membrane During MyelinationIsoform 2: CytoplasmCell MembraneCell JunctionColocalizes With Actb At Tricellular Junctions Between Eye Lens Fiber Cells |
| Alternative Antibody Names | Anti-Periaxin antibodyAnti-PRX antibodyAnti-KIAA1620 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
