Anti-PRRX1 antibody (Internal) (STJ71357)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-PRRX1 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:2000.WB: Approx 28kDa band observed in Human, Mouse and Rat Heart lysates (calculated MW of 27.3kDa according to NP_073207.1). Recommended concentration: 1-3µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | PRRX1 |
| Gene ID | 5396 |
| Uniprot ID | PRRX1_HUMAN |
| Accession Number | NP_008833.1; NP_073207.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | QADENVGEAGRS |
| Specificity | This antibody is expected to recognise both reported isoforms (NP_008833.1; NP_073207.1) ;Concentration=0.5 mg/mL" |
Additional Info
| Function | Master transcription factor of stromal fibroblasts for myofibroblastic lineage progression. Orchestrates the functional drift of fibroblasts into myofibroblastic phenotype via TGF-beta signaling by remodeling a super-enhancer landscape. Through this function, plays an essential role in wound healing process. Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer. May play a role in homeostasis and regeneration of bone, white adipose tissue and derm. Isoform 1: Transcriptional activator, when transfected in fibroblastic or myoblastic cell lines. This activity may be masked by the C-terminal OAR domain. Isoform 2: Transcriptional repressor, when transfected in fibroblastic or myoblastic cell lines. |
| Protein Name | Paired Mesoderm Homeobox Protein 1Homeobox Protein Phox1Paired-Related Homeobox Protein 1Prx-1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Paired Mesoderm Homeobox Protein 1 antibodyAnti-Homeobox Protein Phox1 antibodyAnti-Paired-Related Homeobox Protein 1 antibodyAnti-Prx-1 antibodyAnti-PRRX1 antibodyAnti-PMX1 antibody |
Information sourced from Uniprot.org