| Tissue Specificity | Most abundant in kidney and liver. Also highly expressed in brain, spleen, testis and placenta. Overexpressed in several colorectal tumors. |
| Function | Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer. |
| Protein Name | Proline-Rich Protein 5Protein Observed With Rictor-1Protor-1 |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-389357Reactome: R-HSA-5218920Reactome: R-HSA-5674400Reactome: R-HSA-6804757 |
| Alternative Antibody Names | Anti-Proline-Rich Protein 5 antibodyAnti-Protein Observed With Rictor-1 antibodyAnti-Protor-1 antibodyAnti-PRR5 antibodyAnti-PROTOR1 antibodyAnti-PP610 antibody |
Information sourced from Uniprot.org
