| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PRR5 |
| Gene ID: | 55615 |
| Uniprot ID: | PRR5_HUMAN |
| Immunogen Region: | 190-388 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 190-388 of human PRR5 (NP_851850.1). |
| Immunogen Sequence: | SRGVTEDYLRLETLVQKVVS PYLGTYGLHSSEGPFTHSCI LEKRLLRRSRSGDVLAKNPV VRSKSYNTPLLNPVQEHEAE GAAAGGTSIRRHSVSEMTSC PEPQGFSDPPGQGPTGTFRS SPAPHSGPCPSRLYPTTQPP EQGLDPTRSSLPRSSPENLV DQILESVDSDSEGIFIDFGR GRGSGMSDLEGSGGRQSVV |
| Tissue Specificity | Most abundant in kidney and liver. Also highly expressed in brain, spleen, testis and placenta. Overexpressed in several colorectal tumors. |
| Function | Associated subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer. |
| Protein Name | Proline-Rich Protein 5Protein Observed With Rictor-1Protor-1 |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-389357Reactome: R-HSA-5218920Reactome: R-HSA-5674400Reactome: R-HSA-6804757Reactome: R-HSA-9856530 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Proline-Rich Protein 5 antibodyAnti-Protein Observed With Rictor-1 antibodyAnti-Protor-1 antibodyAnti-PRR5 antibodyAnti-PROTOR1 antibodyAnti-PP610 antibody |
Information sourced from Uniprot.org
