| Host: | Rabbit |
| Applications: | IHC/IF/WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Pre-mRNA-processing factor 6 (747-796 aa) is suitable for use in Immunohistochemistry, Immunofluorescence, Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PRPF6 |
| Gene ID: | 24148 |
| Uniprot ID: | PRP6_HUMAN |
| Immunogen Region: | 747-796 aa |
| Specificity: | PRP6 Polyclonal Antibody detects endogenous levels of PRP6 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human PRPF6 at the amino acid range 747-796 |
| Post Translational Modifications | Phosphorylated by PRP4K during spliceosome assembly. |
| Function | Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. |
| Protein Name | Pre-Mrna-Processing Factor 6Androgen Receptor N-Terminal Domain-Transactivating Protein 1Ant-1Prp6 HomologU5 Snrnp-Associated 102 Kda ProteinU5-102 Kda Protein |
| Database Links | Reactome: R-HSA-72163Reactome: R-HSA-72165 |
| Cellular Localisation | NucleusNucleoplasmNucleus SpeckleLocalized In Splicing Speckles |
| Alternative Antibody Names | Anti-Pre-Mrna-Processing Factor 6 antibodyAnti-Androgen Receptor N-Terminal Domain-Transactivating Protein 1 antibodyAnti-Ant-1 antibodyAnti-Prp6 Homolog antibodyAnti-U5 Snrnp-Associated 102 Kda Protein antibodyAnti-U5-102 Kda Protein antibodyAnti-PRPF6 antibodyAnti-C20orf14 antibody |
Information sourced from Uniprot.org