Anti-PROX1 antibody [R02-8G5] (STJA0036400)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human PROX1
General Information
| Short Description | Rabbit monoclonal anti-PROX1 for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R02-8G5 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | PROX1 |
| Gene ID | 5629 |
| Uniprot ID | PROX1_HUMAN |
| Immunogen | A synthesized peptide derived from human PROX1 |
Additional Info
| Tissue Specificity | Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas. |
| Function | Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. |
| Protein Name | Prospero Homeobox Protein 1Homeobox Prospero-Like Protein Prox1Prox-1 |
| Database Links | |
| Cellular Localisation | NucleusRorg Promotes Its Nuclear Localization |
| Alternative Antibody Names | Anti-Prospero Homeobox Protein 1 antibodyAnti-Homeobox Prospero-Like Protein Prox1 antibodyAnti-Prox-1 antibodyAnti-PROX1 antibody |
Information sourced from Uniprot.org