| Function | Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation. |
| Protein Name | 15-Hydroxyprostaglandin Dehydrogenase Nad(+15-PgdhEicosanoid/Docosanoid Dehydrogenase Nad(+Prostaglandin Dehydrogenase 1Short Chain Dehydrogenase/Reductase Family 36c Member 1 |
| Database Links | Reactome: R-HSA-2142700Reactome: R-HSA-2162123Reactome: R-HSA-9018676Reactome: R-HSA-9018896 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-15-Hydroxyprostaglandin Dehydrogenase Nad(+ antibodyAnti-15-Pgdh antibodyAnti-Eicosanoid/Docosanoid Dehydrogenase Nad(+ antibodyAnti-Prostaglandin Dehydrogenase 1 antibodyAnti-Short Chain Dehydrogenase/Reductase Family 36c Member 1 antibodyAnti-HPGD antibodyAnti-PGDH1 antibodyAnti-SDR36C1 antibody |
Information sourced from Uniprot.org
