![Anti-PROM1 antibody [W6B3C1] {PE} (STJA0002550)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/148334/292954/STJA0002550_1__00939.1631207044.jpg?c=1 "Anti-PROM1 antibody [W6B3C1] {PE} (STJA0002550)")
![Anti-PROM1 antibody [W6B3C1] {PE} (STJA0002550)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/148334/292954/STJA0002550_1__00939.1631207044.jpg?c=1 "Anti-PROM1 antibody [W6B3C1] {PE} (STJA0002550)")
| Host: | Mouse |
| Applications: | FC |
| Reactivity: | Human |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Prominin-1 is suitable for use in Flow Cytometry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | W6B3C1 |
| Conjugation: | PE |
| Isotype: | IgG1k |
| Formulation: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Concentration: | 5 Mu L/Test |
| Storage Instruction: | Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
| Gene Symbol: | PROM1 |
| Gene ID: | 8842 |
| Uniprot ID: | PROM1_HUMAN |
| Tissue Specificity | Isoform 1 is selectively expressed on CD34 hematopoietic stem and progenitor cells in adult and fetal bone marrow, fetal liver, cord blood and adult peripheral blood. Isoform 1 is not detected on other blood cells. Isoform 1 is also expressed in a number of non-lymphoid tissues including retina, pancreas, placenta, kidney, liver, lung, brain and heart. Found in saliva within small membrane particles. Isoform 2 is predominantly expressed in fetal liver, skeletal muscle, kidney, and heart as well as adult pancreas, kidney, liver, lung, and placenta. Isoform 2 is highly expressed in fetal liver, low in bone marrow, and barely detectable in peripheral blood. Isoform 2 is expressed on hematopoietic stem cells and in epidermal basal cells (at protein level). Expressed in adult retina by rod and cone photoreceptor cells (at protein level). |
| Post Translational Modifications | Isoform 1 and isoform 2 are glycosylated. Acetylation at Lys-225, Lys-257 and Lys-264 by NAT8 and NAT8B may control PROM1 protein expression and its function in cell apoptosis. |
| Function | May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. |
| Protein Name | Prominin-1 Antigen Ac133 Prominin-Like Protein 1 Cd Antigen Cd133 |
| Cellular Localisation | Apical Cell Membrane Multi-Pass Membrane Protein Cell Projection Microvillus Membrane Cilium Photoreceptor Outer Segment Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Found In Extracellular Membrane Particles In Various Body Fluids Such As Cerebrospinal Fluid Saliva Seminal Fluid And Urine |
| Alternative Antibody Names | Anti-Prominin-1 antibody Anti-Antigen Ac133 antibody Anti-Prominin-Like Protein 1 antibody Anti-Cd Antigen Cd133 antibody Anti-PROM1 antibody Anti-PROML1 antibody Anti-MSTP061 antibody |
Information sourced from Uniprot.org