Anti-Profilin antibody (50-100) {FITC} (STJ506120)

Name: Anti-Profilin antibody (50-100) {FITC} (STJ506120)
SKU: STJ506120-100
Price: 597 EUR
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationFITC

IsotypeIgG

ImmunogenSynthetic peptide corresponding to amino acids within region 50-100 on human Profilin 1.

STJ506120-100

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Short Description	Rabbit polyclonal antibody anti-Profilin (50-100) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Applications	ELISA/IP/WB
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	FITC
Concentration	0.5-1.5 µg/µl
Purification	Affinity Purified
Dilution Range	WB: 1:500-1:5, 000 ELISA: 1:50, 000 IP: 1:200
Formulation	Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide).
Storage Instruction	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol	PFN1
Gene ID	5216
Uniprot ID	PROF1_HUMAN
Immunogen	Synthetic peptide corresponding to amino acids within region 50-100 on human Profilin 1.
Immunogen Region	50-100

Tissue Specificity	Expressed in epididymis (at protein level).
Post Translational Modifications	Phosphorylation at Ser-138 reduces its affinity for G-actin and blocks its interaction with HTT, reducing its ability to inhibit androgen receptor (AR) and HTT aggregation.
Function	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.
Protein Name	Profilin-1 Epididymis Tissue Protein Li 184a Profilin I
Database Links	Reactome: R-HSA-114608 Reactome: R-HSA-376176 Reactome: R-HSA-4086400 Reactome: R-HSA-5663220
Cellular Localisation	Cytoplasm Cytoskeleton
Alternative Antibody Names	Anti-Profilin-1 antibody Anti-Epididymis Tissue Protein Li 184a antibody Anti-Profilin I antibody Anti-PFN1 antibody

Information sourced from Uniprot.org