STJ71379 (0. 3µg/ml) staining of Human Adrenal Gland lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-Proenkephalin antibody (Internal) (STJ71379)

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STJ71379-100
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Host: Goat
Applications: Pep-ELISA/WB/IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Goat polyclonal antibody anti-Proenkephalin (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: Peptide ELISA: antibody detection limit dilution 1:32000.
WB: Approx 37kDa band observed in Human Adrenal Gland lysates (calculated MW of 30.8kDa according to NP_006202.1). The observed molecular weight corresponds to earlier findings in literatu
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: PENK
Gene ID: 5179
Uniprot ID: PENK_HUMAN
Immunogen Region: Internal
Accession Number: NP_006202.1
Immunogen Sequence: RSHHQDGSDNEE
Function Met-enkephalin: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. Leu-enkephalin: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. Met-enkephalin-Arg-Phe: Met-enkephalin-Arg-Phe neuropeptide acts as a strong ligand of Mu-type opioid receptor OPRM1. Met-enkephalin-Arg-Phe-binding to OPRM1 in the nucleus accumbens of the brain increases activation of OPRM1, leading to long-term synaptic depression of glutamate release. PENK(114-133): Increases glutamate release in the striatum and decreases GABA concentration in the striatum. PENK(237-258): Increases glutamate release in the striatum.
Protein Name Proenkephalin-A Cleaved Into - Synenkephalin - Met-Enkephalin
Opioid Growth Factor
Ogf - Penk(114-133 - Penk(143-183 - Met-Enkephalin-Arg-Gly-Leu - Leu-Enkephalin - Penk(237-258 - Met-Enkephalin-Arg-Phe
Database Links Reactome: R-HSA-375276
Reactome: R-HSA-381426
Reactome: R-HSA-418594
Reactome: R-HSA-8957275
Cellular Localisation Cytoplasmic Vesicle
Secretory Vesicle
Chromaffin Granule Lumen
Secreted
Alternative Antibody Names Anti-Proenkephalin-A Cleaved Into - Synenkephalin - Met-Enkephalin antibody
Anti-Opioid Growth Factor antibody
Anti-Ogf - Penk(114-133 - Penk(143-183 - Met-Enkephalin-Arg-Gly-Leu - Leu-Enkephalin - Penk(237-258 - Met-Enkephalin-Arg-Phe antibody
Anti-PENK antibody

Information sourced from Uniprot.org

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