| Host: |
Goat |
| Applications: |
Pep-ELISA/WB/IHC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-Proenkephalin (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
IHC-0.3-1µg/mlELISA-antibody detection limit dilution 1:32000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
PENK |
| Gene ID: |
5179 |
| Uniprot ID: |
PENK_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_006202.1 |
| Immunogen Sequence: |
RSHHQDGSDNEE |
| Function | Met-enkephalin: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. Leu-enkephalin: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. Met-enkephalin-Arg-Phe: Met-enkephalin-Arg-Phe neuropeptide acts as a strong ligand of Mu-type opioid receptor OPRM1. Met-enkephalin-Arg-Phe-binding to OPRM1 in the nucleus accumbens of the brain increases activation of OPRM1, leading to long-term synaptic depression of glutamate release. PENK(114-133): Increases glutamate release in the striatum and decreases GABA concentration in the striatum. PENK(237-258): Increases glutamate release in the striatum. |
| Protein Name | Proenkephalin-A Cleaved Into - Synenkephalin - Met-EnkephalinOpioid Growth FactorOgf - Penk(114-133 - Penk(143-183 - Met-Enkephalin-Arg-Gly-Leu - Leu-Enkephalin - Penk(237-258 - Met-Enkephalin-Arg-Phe |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-381426Reactome: R-HSA-418594Reactome: R-HSA-8957275 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleChromaffin Granule LumenSecreted |
| Alternative Antibody Names | Anti-Proenkephalin-A Cleaved Into - Synenkephalin - Met-Enkephalin antibodyAnti-Opioid Growth Factor antibodyAnti-Ogf - Penk(114-133 - Penk(143-183 - Met-Enkephalin-Arg-Gly-Leu - Leu-Enkephalin - Penk(237-258 - Met-Enkephalin-Arg-Phe antibodyAnti-PENK antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
