Immunohistochemistry analysis of paraffin-embedded rat kidney using PROCR antibody (STJ115600) at dilution of 1:200 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.

Anti-PROCR antibody (19-209) (STJ115600)

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STJ115600
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Host: Rabbit
Applications: WB/IHC-P/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
IHC-P:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PROCR
Gene ID: 10544
Uniprot ID: EPCR_HUMAN
Immunogen Region: 19-209
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 19-209 of human PROCR (NP_006395.2).
Immunogen Sequence: QDASDGLQRLHMLQISYFRD PYHVWYQGNASLGGHLTHVL EGPDTNTTIIQLQPLQEPES WARTQSGLQSYLLQFHGLVR LVHQERTLAFPLTIRCFLGC ELPPEGSRAHVFFEVAVNGS SFVSFRPERALWQADTQVTS GVVTFTLQQLNAYNRTRYEL REFLEDTCVQYVQKHISAEN TKGSQTSRSYT
Tissue Specificity Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.
Post Translational Modifications N-glycosylated. A soluble form exists.probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form.
Function Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex.plays a role in the protein C pathway controlling blood coagulation.
Protein Name Endothelial Protein C Receptor
Activated Protein C Receptor
Apc Receptor
Endothelial Cell Protein C Receptor
Cd Antigen Cd201
Database Links Reactome: R-HSA-140875
Reactome: R-HSA-202733
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Endothelial Protein C Receptor antibody
Anti-Activated Protein C Receptor antibody
Anti-Apc Receptor antibody
Anti-Endothelial Cell Protein C Receptor antibody
Anti-Cd Antigen Cd201 antibody
Anti-PROCR antibody
Anti-EPCR antibody

Information sourced from Uniprot.org

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