Western blot analysis of extracts of various cell lines, using PROCR antibody (STJ28330) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.

Anti-PROCR antibody (18-210) (STJ28330)

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STJ28330
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PROCR
Gene ID: 10544
Uniprot ID: EPCR_HUMAN
Immunogen Region: 18-210
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 18-210 of human PROCR (NP_006395.2).
Immunogen Sequence: SQDASDGLQRLHMLQISYFR DPYHVWYQGNASLGGHLTHV LEGPDTNTTIIQLQPLQEPE SWARTQSGLQSYLLQFHGLV RLVHQERTLAFPLTIRCFLG CELPPEGSRAHVFFEVAVNG SSFVSFRPERALWQADTQVT SGVVTFTLQQLNAYNRTRYE LREFLEDTCVQYVQKHISAE NTKGSQTSRSYTS
Tissue Specificity Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.
Post Translational Modifications N-glycosylated. A soluble form exists.probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form.
Function Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex.plays a role in the protein C pathway controlling blood coagulation.
Protein Name Endothelial Protein C Receptor
Activated Protein C Receptor
Apc Receptor
Endothelial Cell Protein C Receptor
Cd Antigen Cd201
Database Links Reactome: R-HSA-140875
Reactome: R-HSA-202733
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Endothelial Protein C Receptor antibody
Anti-Activated Protein C Receptor antibody
Anti-Apc Receptor antibody
Anti-Endothelial Cell Protein C Receptor antibody
Anti-Cd Antigen Cd201 antibody
Anti-PROCR antibody
Anti-EPCR antibody

Information sourced from Uniprot.org

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