| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S4142RM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PRMT7 |
| Gene ID: | 54496 |
| Uniprot ID: | ANM7_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PRMT7 (Q9NVM4). |
| Immunogen Sequence: | MKIFCSRANPTTGSVEWLEE DEHYDYHQEIARSSYADMLH DKDRNVKYYQGIRAAVSRVK DRGQKALVLDIGTGTGLLSM MAVTAGADFCYAIEVFKPMA |
| Function | Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3).such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro.the relevance of such results is however unclear in vivo. |
| Protein Name | Protein Arginine N-Methyltransferase 7 Histone-Arginine N-Methyltransferase Prmt7 Myelin Basic Protein-Arginine N-Methyltransferase Prmt7 |
| Database Links | Reactome: R-HSA-3214858 |
| Cellular Localisation | Cytoplasm Cytosol Nucleus |
| Alternative Antibody Names | Anti-Protein Arginine N-Methyltransferase 7 antibody Anti-Histone-Arginine N-Methyltransferase Prmt7 antibody Anti-Myelin Basic Protein-Arginine N-Methyltransferase Prmt7 antibody Anti-PRMT7 antibody Anti-KIAA1933 antibody |
Information sourced from Uniprot.org