| Post Translational Modifications | Phosphorylated at Ser-246 in unstressed cells and at Ser-287 in stressed cells. Phosphorylation at Ser-246 appears to be a prerequisite for subsequent phosphorylation at Ser-287. Phosphorylation at Ser-246 and Ser-287 are necessary for activation of EIF2AK2/PKR under conditions of stress. |
| Function | Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner. |
| Protein Name | Interferon-Inducible Double-Stranded Rna-Dependent Protein Kinase Activator APkr-Associated Protein XPkr-Associating Protein XProtein Activator Of The Interferon-Induced Protein KinaseProtein Kinase - Interferon-Inducible Double-Stranded Rna-Dependent Activator |
| Database Links | Reactome: R-HSA-203927Reactome: R-HSA-426486Reactome: R-HSA-9833482 |
| Cellular Localisation | CytoplasmPerinuclear Region |
| Alternative Antibody Names | Anti-Interferon-Inducible Double-Stranded Rna-Dependent Protein Kinase Activator A antibodyAnti-Pkr-Associated Protein X antibodyAnti-Pkr-Associating Protein X antibodyAnti-Protein Activator Of The Interferon-Induced Protein Kinase antibodyAnti-Protein Kinase - Interferon-Inducible Double-Stranded Rna-Dependent Activator antibodyAnti-PRKRA antibodyAnti-PACT antibodyAnti-RAX antibodyAnti-HSD-14 antibodyAnti-HSD14 antibody |
Information sourced from Uniprot.org
