Anti-PRKG2 antibody (1-160) (STJ11100525)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PRKG2 (1-160) antibody for use in WB, IF, ICC, IP and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/IP/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200IP:0.5 Mu g-4 Mu g antibody for 400 Mu g-600 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PRKG2 |
| Gene ID | 5593 |
| Uniprot ID | KGP2_HUMAN |
| Immunogen Region | 1-160 |
| Immunogen Sequence | MGNGSVKPKHSKHPDGHSGN LTTDALRNKVTELERELRRK DAEIQEREYHLKELREQLSK QTVAIAELTEELQNKCIQLN KLQDVVHMQGGSPLQASPDK VPLEVHRKTSGLVSLHSRRG AKAGVSAEPTTRTYDLNKPP EFSFEKARVRKDSSEKKLIT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human PRKG2 (NP_006250.1). |
Additional Info
| Tissue Specificity | Highly concentrated in brain, lung and intestinal mucosa. |
| Post Translational Modifications | Myristoylation mediates membrane localization. |
| Function | Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum. Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863. Acts as a regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation. |
| Protein Name | Cgmp-Dependent Protein Kinase 2Cgk 2Cgk2Cgmp-Dependent Protein Kinase IiCgkii |
| Database Links | Reactome: R-HSA-1474151Reactome: R-HSA-4086398Reactome: R-HSA-418457Reactome: R-HSA-9648002 |
| Cellular Localisation | Apical Cell MembraneLipid-Anchor |
| Alternative Antibody Names | Anti-Cgmp-Dependent Protein Kinase 2 antibodyAnti-Cgk 2 antibodyAnti-Cgk2 antibodyAnti-Cgmp-Dependent Protein Kinase Ii antibodyAnti-Cgkii antibodyAnti-PRKG2 antibodyAnti-PRKGR2 antibody |
Information sourced from Uniprot.org