Anti-PRKAR2A antibody (1-404) (STJ25123)

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STJ25123
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Short Description :Rabbit polyclonal PRKAR2A (1-404) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications:WB/IF/ICC/ELISA
Host:Rabbit
Reactivity:Human/Mouse/Rat
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Polyclonal
Isotype:IgG
Conjugation:Unconjugated
Concentration:Lot specific
Purification:Affinity purification
Dilution Range:WB:1:1000-1:2000
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation:PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3.
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol:PRKAR2A
Gene ID:5576
Uniprot ID:KAP2_HUMAN
Immunogen Region:1-404
Immunogen Sequence:MSHIQIPPGLTELLQGYTVE VLRQQPPDLVEFAVEYFTRL REARAPASVLPAATPRQSLG HPPPEPGPDRVADAKGDSES EEDEDLEVPVPSRFNRRVSV CAETYNPDEEEEDTDPRVIH PKTDEQRCRLQEACKDILLF KNLDQEQLSQVLDAMFERIV KADEHVIDQGDDGDNFYVIE RGTYDILVTKDNQTRSVGQY DNRGSFGELALMYNTPRAAT IVATSEGSLWGLDRVTFRR
Specificity:Recombinant fusion protein containing a sequence corresponding to amino acids 1-404 of human PKA RII Alpha (PRKAR2A) /PKR2 (NP_004148.1).
Tissue Specificity Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
Post Translational Modifications Phosphorylated by the activated catalytic chain.
Function Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
Protein Name Camp-Dependent Protein Kinase Type Ii-Alpha Regulatory Subunit
Database Links Reactome: R-HSA-163615
Reactome: R-HSA-164378
Reactome: R-HSA-180024
Reactome: R-HSA-381676
Reactome: R-HSA-432040
Reactome: R-HSA-442720
Reactome: R-HSA-5610787
Reactome: R-HSA-9010642
Reactome: R-HSA-9634597
Reactome: R-HSA-9660821
Reactome: R-HSA-9664323
Reactome: R-HSA-983231
Reactome: R-HSA-9856530
Cellular Localisation Cytoplasm
Cell Membrane
Colocalizes With Pja2 In The Cytoplasm And The Cell Membrane
Alternative Antibody Names Anti-Camp-Dependent Protein Kinase Type Ii-Alpha Regulatory Subunit antibody
Anti-PRKAR2A antibody
Anti-PKR2 antibody
Anti-PRKAR2 antibody

Information sourced from Uniprot.org