| Host: |
Goat |
| Applications: |
Pep-ELISA |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-PRICKLE3/LMO6 (Internal) is suitable for use in ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
ELISA-antibody detection limit dilution 1:4000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
PRICKLE3 |
| Gene ID: |
4007 |
| Uniprot ID: |
PRIC3_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_006141.2 |
| Immunogen Sequence: |
PDRGQPCNSCR |
| Function | Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation. PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module. Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions. Involved in the organization of the basal body. Involved in cilia growth and positioning. Required for proper assembly, stability, and function of mitochondrial membrane ATP synthase (mitochondrial complex V). |
| Protein Name | Prickle Planar Cell Polarity Protein 3Lim Domain Only Protein 6Lmo-6Prickle-Like Protein 3Pk3Triple Lim Domain Protein 6 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinCytoplasmic SideMitochondrionRecruited By Vangl2 To Anterior Cell BordersThis Polarity Is Controlled By Wnt ProteinsWtip Is Involved In The Recruitment Of Prickle3 To The Basal Body |
| Alternative Antibody Names | Anti-Prickle Planar Cell Polarity Protein 3 antibodyAnti-Lim Domain Only Protein 6 antibodyAnti-Lmo-6 antibodyAnti-Prickle-Like Protein 3 antibodyAnti-Pk3 antibodyAnti-Triple Lim Domain Protein 6 antibodyAnti-PRICKLE3 antibodyAnti-LMO6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
