Anti-PRG4 antibody (STJA0009782)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human Lubricin/MSF
General Information
| Short Description | Rabbit polyclonal anti-Proteoglycan 4 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PRG4 |
| Gene ID | 10216 |
| Uniprot ID | PRG4_HUMAN |
| Immunogen | Synthesized peptide derived from human Lubricin/MSF |
| Specificity | This antibody detects endogenous levels of Lubricin/MSF at Human, Mouse |
Additional Info
| Post Translational Modifications | N-glycosylated. O-glycosylated.contains glycosaminoglycan chondroitin sulfate and keratan sulfate. O-glycosylated with sialylated oligosaccharides which are predominantly represented by the monosialylated core type I structure, NeuNAcalpha2-3Galbeta1-3GalNAc, with smaller amounts of disialylated O-glycans. The disulfide bond between Cys-1146 and Cys-1403 is essential for protein cleavage. Proteolytically cleaved by cathepsin CTSG. |
| Function | Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface. Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages. |
| Protein Name | Proteoglycan 4LubricinMegakaryocyte-Stimulating FactorSuperficial Zone Proteoglycan Cleaved Into - Proteoglycan 4 C-Terminal Part |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Proteoglycan 4 antibodyAnti-Lubricin antibodyAnti-Megakaryocyte-Stimulating Factor antibodyAnti-Superficial Zone Proteoglycan Cleaved Into - Proteoglycan 4 C-Terminal Part antibodyAnti-PRG4 antibodyAnti-MSF antibodyAnti-SZP antibody |
Information sourced from Uniprot.org